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Kanno, H. et al.

Kanno, Yamamoto, Yoshida, Kitamura,

Meningioma showing VHL gene inactivation in a patient with von Hippel-Lindau disease.

The genetic mechanism of the tumorigenesis of meningioma in conjunction with von Hippel-Lindau (VHL) disease is unclear. The authors present a case of VHL disease associated with a posterior fossa meningioma and with multiple cerebellar hemangioblastomas. A germline mutation of the VHL gene and loss of heterozygosity on the VHL gene locus in 3p were detected in the meningioma. Tumorigenesis of a meningioma associated with VHL disease could be caused by inactivation of both alleles of the VHL gene.[1]

References

Meningioma showing VHL gene inactivation in a patient with von Hippel-Lindau disease. Kanno, H., Yamamoto, I., Yoshida, M., Kitamura, H. Neurology (2003) [Pubmed]

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