- Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigen. Tonnelle, C., Imbert, M.C., Sainty, D., Granjeaud, S., N'Guyen, C., Chabannon, C. Hematol. J. (2003)