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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle.

Rat ERK6, also known as SAPK3 and p38gamma, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function.[1]

References

  1. ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle. Tortorella, L.L., Lin, C.B., Pilch, P.F. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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