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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Mak, T.W. et al.

Mak, Shahinian, Yoshinaga, Wakeham, Boucher, Pintilie, Duncan, Gajewska, Gronski, Eriksson, Odermatt, Ho, Bouchard, Whorisky, Jordana, Ohashi, Pawson, Bladt, Tafuri,

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.

Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.[1]

References

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Mak, T.W., Shahinian, A., Yoshinaga, S.K., Wakeham, A., Boucher, L.M., Pintilie, M., Duncan, G., Gajewska, B.U., Gronski, M., Eriksson, U., Odermatt, B., Ho, A., Bouchard, D., Whorisky, J.S., Jordana, M., Ohashi, P.S., Pawson, T., Bladt, F., Tafuri, A. Nat. Immunol. (2003) [Pubmed]

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