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Poreddy, A.R. et al.

Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents.

A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a-d, with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium.[1]

References

Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents. Poreddy, A.R., Schall, O.F., Marshall, G.R., Ratledge, C., Slomczynska, U. Bioorg. Med. Chem. Lett. (2003) [Pubmed]

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