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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity.

Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.[1]

References

  1. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Son, J.K., Park, J.S., Kim, J.A., Kim, Y., Chung, S.R., Lee, S.H. Planta Med. (2003) [Pubmed]
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