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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury.

PURPOSE: The purpose of this paper is to clarify the relationship between cytokines, matrix metalloproteinase-1 (MMP-1) and severity of acute myocardial infarction (AMI). Additionally, to investigate whether magnesium (Mg) sulfate pretreatment inhibits myocardial damage in coronary reperfusion therapy for patients with AMI. SUBJECTS: At first, 34 patients with AMI were enrolled. Then, the patients were classified into 2 groups with or without congestive heart failure (CHF) (C group and NC group, respectively). Interleukin 6 (IL-6), MMP-1 and the hemodynamic parameters were measured. Second, 36 AMI patients treated with coronary reperfusion therapy were enrolled. Patients were divided into 2 groups (18 patients each) as the non-pretreated group (Control group) and the group pretreated with intravenous Mg sulfate (0.27 mmol/kg) (Mg group). IL-6, MMP-1 and the indexes of reperfusion injury were evaluated. RESULTS: There were positive correlations between peak MMP-1 level, and peak creatine kinase value and pulmonary capillary wedge pressure and peak IL-6 level (r = 0.43, r = 0.70, and r = 0.60, respectively) in all patients. There were negative correlations between peak MMP-1 level and left ventricular ejection fraction and cardiac index (r = - 0.52 and r = - 0.55, respectively). The peak blood IL-6 and MMP-1 level increased in AMI, particularly in patients with CHF (C group vs NC group; 130 vs 51 pg/mL and 37 vs 18 ng/mL, both p < 0.01). Additionally, peak IL-6 and peak MMP-1 in the Mg group were lower than those of the control group (39 vs 92 pg/mL and 16 vs 20 ng/mL, p < 0.05 and p = 0.09, respectively). The incidence of reperfusion injury including reperfusion arrhythmia and transient exacerbation of ST elevation in the Mg group was lower than that of control group (17 vs 78% and 2.5 vs 4.7 mm, p < 0.01 and p = 0.08, respectively). CONCLUSION: These results may suggest that the severity of AMI is reflected by the blood IL-6 and MMP-1 levels and that pretreatment with Mg administration protects the myocardium of patients with AMI from reperfusion injury induced by IL-6 and MMP-1.[1]

References

  1. Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury. Ueshima, K., Shibata, M., Suzuki, T., Endo, S., Hiramori, K. Magnesium research : official organ of the International Society for the Development of Research on Magnesium. (2003) [Pubmed]
 
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