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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation.

Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute. This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes.[1]

References

  1. The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation. zur Lage, P.I., Prentice, D.R., Holohan, E.E., Jarman, A.P. Development (2003) [Pubmed]
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