Beta-agonists and asthma: too much of a good thing?

J Clin Invest. 2003 Aug;112(4):495-7. doi: 10.1172/JCI19642.

Abstract

In an unusual paradox, asthmatics who are chronically treated with bronchodilating beta-agonists sometimes experience a worsening of their condition. A new study describes one possible mechanism and reveals a potential new therapeutic target in the treatment of asthma.

Publication types

  • Comment
  • Review

MeSH terms

  • Adrenergic beta-Agonists / adverse effects
  • Adrenergic beta-Agonists / therapeutic use*
  • Animals
  • Asthma / drug therapy*
  • Bronchi / drug effects
  • Humans
  • Ligands
  • Models, Biological
  • Protein Binding
  • Receptors, Adrenergic, beta-2 / metabolism
  • Signal Transduction

Substances

  • Adrenergic beta-Agonists
  • Ligands
  • Receptors, Adrenergic, beta-2