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Adinoff, B. et al.

Adinoff, Devous, Best, Harris, Chandler, Frock, Williams,

Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation.

BACKGROUND: Cocaine dependence follows a different disease course in men and women, possibly as a consequence of sex-specific neurobiologic responses to chronic cocaine use. We have previously reported that male cocaine-dependent subjects demonstrate a significantly different limbic response to the limbic-stimulus procaine, as measured by regional cerebral blood flow (rCBF), compared with male controls. In this study, we assessed the limbic rCBF response to procaine in female cocaine-addicted subjects (n=10) and female controls (n=10). METHODS: Subjects were administered 1.38 mg/kg procaine or saline intravenously in two separate sessions. Single photon emission computed tomography (SPECT) was used to compare the rCBF response to procaine. RESULTS: Female cocaine-dependent subjects demonstrate a markedly muted, and distinctly different, limbic response to procaine compared with matched healthy controls. CONCLUSIONS: The rCBF response to procaine in female cocaine-dependent subjects suggests significant CNS differences compared with non-addicted female controls. Coupled with findings previously observed in male cocaine-dependent subjects, these biologic differences suggest that both male and female subjects experience alterations in limbic responsiveness following the chronic use of cocaine.[1]

References

Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation. Adinoff, B., Devous, M.D., Best, S.E., Harris, T.S., Chandler, P., Frock, S.D., Williams, M.J. Drug and alcohol dependence. (2003) [Pubmed]

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