Abstract
Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.
MeSH terms
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Animals
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Antigens, Bacterial / immunology*
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Antigens, Bacterial / pharmacology
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Bronchoalveolar Lavage Fluid / cytology
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Bronchoalveolar Lavage Fluid / immunology
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Cell Movement
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Disease Models, Animal
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Drug Synergism
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Enzyme-Linked Immunosorbent Assay
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Immunohistochemistry
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Lipopolysaccharides / immunology*
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Lipopolysaccharides / pharmacology
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Lung / immunology
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Lung / pathology
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Mice
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Mice, Inbred BALB C
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Neutrophils / immunology*
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Peptidoglycan / immunology*
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Peptidoglycan / pharmacology
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Pneumonia, Staphylococcal / immunology*
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Pneumonia, Staphylococcal / pathology
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Staphylococcus aureus / immunology
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Teichoic Acids / immunology*
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Teichoic Acids / pharmacology
Substances
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Antigens, Bacterial
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Lipopolysaccharides
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Peptidoglycan
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Teichoic Acids
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lipoteichoic acid