Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice

Clin Diagn Lab Immunol. 2003 Sep;10(5):950-3. doi: 10.1128/cdli.10.5.950-953.2003.

Abstract

Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology*
  • Antigens, Bacterial / pharmacology
  • Bronchoalveolar Lavage Fluid / cytology
  • Bronchoalveolar Lavage Fluid / immunology
  • Cell Movement
  • Disease Models, Animal
  • Drug Synergism
  • Enzyme-Linked Immunosorbent Assay
  • Immunohistochemistry
  • Lipopolysaccharides / immunology*
  • Lipopolysaccharides / pharmacology
  • Lung / immunology
  • Lung / pathology
  • Mice
  • Mice, Inbred BALB C
  • Neutrophils / immunology*
  • Peptidoglycan / immunology*
  • Peptidoglycan / pharmacology
  • Pneumonia, Staphylococcal / immunology*
  • Pneumonia, Staphylococcal / pathology
  • Staphylococcus aureus / immunology
  • Teichoic Acids / immunology*
  • Teichoic Acids / pharmacology

Substances

  • Antigens, Bacterial
  • Lipopolysaccharides
  • Peptidoglycan
  • Teichoic Acids
  • lipoteichoic acid