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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Induction of differentiation of the human promyelocytic cell line HL-60 by activin/EDF.

A human promyelocytic cell line, HL-60, treated with activin/EDF was found to differentiate into monocyte/macrophage-like cells. This was shown not only by morphology but by the loss of myeloperoxidase granules and the appearance of nonspecific esterase. Dose-dependent inhibition of the differentiation by follistatin, an activin-binding protein, confirmed that it was indeed caused by activin. Thus, activin/EDF exerts its effect on hematopoietic cells not only on erythroid differentiation but also on at least a part of myeloid cell differentiation.[1]

References

  1. Induction of differentiation of the human promyelocytic cell line HL-60 by activin/EDF. Yamada, R., Suzuki, T., Hashimoto, M., Eto, Y., Shiokawa, K., Muramatsu, M. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
 
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