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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1.

Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.[1]

References

  1. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Ericson, J., Thor, S., Edlund, T., Jessell, T.M., Yamada, T. Science (1992) [Pubmed]
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