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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Nerve-dependent expression of c-myc protein during forelimb regeneration of Xenopus laevis froglets.

The consequences of denervation on the expression of c-myc protein have been analyzed on the regenerating forelimb of young froglets of Xenopus laevis. The level of c-myc expression, low in control limbs and enhanced in the regenerate, is transiently increased after a three-hour total denervation. For this protein, the level of expression is not a function of the quantity of nerve in the regenerate. Four days after denervation, c-myc signal is back to its base level observed in the regenerate. A different pattern of expression is obtained for an S phase marker (PCNA protein) taken as a control in the same experimental conditions. The data presented here show that the nervous system normally exerts a negative control on the expression of c-myc and PCNA proteins in the limb regenerate of Xenopus.[1]

References

  1. Nerve-dependent expression of c-myc protein during forelimb regeneration of Xenopus laevis froglets. Lemaître, J.M., Méchali, M., Géraudie, J. Int. J. Dev. Biol. (1992) [Pubmed]
 
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