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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Induction of micronuclei in BALB/c-3T3 cells by selected chemicals and complex mixtures.

The genotoxicity of benzo[a]pyrene, cyclophosphamide, 2-aminoanthracene, 2-nitrofluorene, nitrosated coal-dust extracts, and cigarette-smoke condensate were tested with the micronucleus assay using an established mammalian cell line. The results showed that all chemicals and complex mixtures studied induced micronuclei in BALB/c-3T3 cells. These results indicate that BALB/c-3T3 cells are capable of activating certain promutagens and procarcinogens. It seems, therefore, that in addition to cell transformation, the micronucleus assay in BALB/c-3T3 cells without an exogenous activation system may be useful for in vitro studies to detect genotoxic chemicals and complex mixtures.[1]

References

  1. Induction of micronuclei in BALB/c-3T3 cells by selected chemicals and complex mixtures. Gu, Z.W., Whong, W.Z., Wallace, W.E., Ong, T.M. Mutat. Res. (1992) [Pubmed]
 
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