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Platelet aggregation inhibitors from Populus sieboldii Miquel.

The water extract of Populus sieboldii Miquel (Salicaceae) inhibited arachidonic acid-induced platelet aggregation. Pyrocatechol and salicyl alcohol were isolated as active constituents. Pyrocatechol showed an inhibitory effect on platelet aggregation induced by arachidonic acid with IC100 value of 4 microM, which was 25 times more potent than aspirin.[1]

References

  1. Platelet aggregation inhibitors from Populus sieboldii Miquel. Kagawa, K., Tokura, K., Uchida, K., Kakushi, H., Shike, T. Chem. Pharm. Bull. (1992) [Pubmed]
 
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