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Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study.

Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen. There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). The actual frequency of hiccup was not significantly altered by the medication. We propose that the mechanical aspects of hiccup are reduced by Baclofen, leading to a perceptual blockage and a decrease in the reflex severity induced by the gamma-aminobutyric acid analogue. We conclude that this medication may be useful for the treatment of intractable hiccup.[1]

References

  1. Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study. Ramírez, F.C., Graham, D.Y. Am. J. Gastroenterol. (1992) [Pubmed]
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