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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome.

We describe an unusual mechanism for organelle division. In the yeast Yarrowia lipolytica, only mature peroxisomes contain the complete set of matrix proteins. These mature peroxisomes assemble from several immature peroxisomal vesicles in a multistep pathway. The stepwise import of distinct subsets of matrix proteins into different immature intermediates along the pathway causes the redistribution of a peroxisomal protein, acyl-CoA oxidase ( Aox), from the matrix to the membrane. A significant redistribution of Aox occurs only in mature peroxisomes. Inside mature peroxisomes, the membrane-bound pool of Aox interacts with Pex16p, a membrane-associated protein that negatively regulates the division of early intermediates in the pathway. This interaction inhibits the negative action of Pex16p, thereby allowing mature peroxisomes to divide.[1]

References

  1. Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome. Guo, T., Kit, Y.Y., Nicaud, J.M., Le Dall, M.T., Sears, S.K., Vali, H., Chan, H., Rachubinski, R.A., Titorenko, V.I. J. Cell Biol. (2003) [Pubmed]
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