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Lu, Z. et al.

Lu, Bohn, Bergeron, Deng, Ellsworth, Geissler, Harris, McCann, McKeever, Myers, Saperstein, Willoughby, Yao, Chapman,

A new class of glycogen phosphorylase inhibitors.

A new class of diacid analogues that binds at the AMP site not only are very potent but have approximately 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.[1]

References

A new class of glycogen phosphorylase inhibitors. Lu, Z., Bohn, J., Bergeron, R., Deng, Q., Ellsworth, K.P., Geissler, W.M., Harris, G., McCann, P.E., McKeever, B., Myers, R.W., Saperstein, R., Willoughby, C.A., Yao, J., Chapman, K. Bioorg. Med. Chem. Lett. (2003) [Pubmed]

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