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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Zhang, B. et al.

Getting secretory granules ready for prime time.

Several rare human diseases have shed important light on the secretory pathway required for lymphocyte cytotoxicity. In this issue of Cell, Feldmann et al. identify mutations in Munc13-4 as a cause of familial hemophagocytic lymphohistiocytosis. Munc13-4 appears to be involved in the priming of cytotoxic granules prior to fusion with the plasma membrane.[1]

References

Getting secretory granules ready for prime time. Zhang, B., Ginsburg, D. Cell (2003) [Pubmed]

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