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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.

We report the management of a 15-year-old boy with an anaphylactic or anaphylactoid response to his first dose of methotrexate during induction therapy for acute lymphoblastic leukemia (ALL). Because weekly methotrexate therapy is an important component of continuation chemotherapy for pediatric ALL, a stepwise graded challenge was employed to achieve drug tolerance.[1]

References

  1. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. MacGinnitie, A.J., Walensky, L.D., Turvey, S.E., Orange, J.S., Bonilla, F.A., Silverman, L.B., Oettgen, H. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2003) [Pubmed]
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