The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Age dependency of serum insulin - like growth factor (IGF)-1 in healthy Turkish adolescents and adults.

BACKGROUND: Serum levels of insulin-like growth factor-1 (IGF-1) reflect endogenous growth hormone (GH) secretion in healthy subjects. Measurements of IGF-1 are useful for diagnosis and follow-up of patients with acromegaly and the diagnosis of GH deficiency in children. AIMS: To assess age dependency and normal ranges of serum IGF-1 levels in healthy Turkish population. SETTING AND DESIGN: We therefore studied 272 healthy adolescents and adults between 15-75 years of age. None had diabetes or other endocrine disease or had received estrogen therapy. MATERIAL AND METHODS: Height, weight, body mass index (BMI) and waist-hip ratio were measured in all subjects. Serum samples were obtained during morning hours and IGF-1 was measured by radioimmunoassay. STATISTICAL ANALYSIS: The age-dependent reference range for serum IGF-1 concentrations was calculated by simple least linear regression analysis: the regression line represents the means with 95 percent confidence intervals. Correlation analysis was also done. RESULTS: Ageing was negatively related to serum levels of IGF-1 (P= 0.0001, r=-0.931) with a mean decrease (youngest vs. oldest). IGF-1 levels increased during adolescence, with the highest mean values during puberty. After puberty, a subsequent decline in serum levels of IGF-1 was apparent. There were also a significant difference according to gender; females had significantly higher levels (357.909+/-219.167 mg/L) than males (307.962+/-198.41 mg/L) (P=0.012). IGF-1 levels were correlated with body height (P=0.001, r=0.223), body weight (P=0.002,r=-0.188) and BMI (P=0.039, r=0.128). CONCLUSION: IGF-1 serum levels increase in adolescents with a peak in puberty, whereafter IGF-1 levels return to prepubertal levels.[1]

References

  1. Age dependency of serum insulin - like growth factor (IGF)-1 in healthy Turkish adolescents and adults. Tiryakioğlu, O., Kadiolgu, P., Canerolgu, N.U., Hatemi, H. Indian journal of medical sciences. (2003) [Pubmed]
 
WikiGenes - Universities