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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TRPV4 calcium entry channel: a paradigm for gating diversity.

The vanilloid receptor-1 (VR1, now TRPV1) was the founding member of a subgroup of cation channels within the TRP family. The TRPV subgroup contains six mammalian members, which all function as Ca2+ entry channels gated by a variety of physical and chemical stimuli. TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4alpha-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids. This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels.[1]

References

  1. TRPV4 calcium entry channel: a paradigm for gating diversity. Nilius, B., Vriens, J., Prenen, J., Droogmans, G., Voets, T. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
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