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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens.

BACKGROUND: It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate. METHODS: The prostates of male Long-Evans rats fed a diet high in phytoestrogens (Phyto-600) or very low levels of phytoestrogens (Phyto-free) were analyzed to determine the impact of dietary phytoestrogens on prostate weight and androgen receptor (AR) expression in the prostate. RESULTS: Dietary phytoestrogens significantly decreased post-pubertal prostate weight gain in Phyto-600 vs Phyto-free fed males. Additionally, dietary phytoestrogens (Phyto-600) decreased AR expression in the prostate as determined by in situ hybridization. CONCLUSIONS: Soy phytoestrogens, present in diet, alter prostate growth presumably by binding ER-beta and subsequently reducing AR expression within the prostate.[1]

References

  1. Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens. Lund, T.D., Munson, D.J., Adlercreutz, H., Handa, R.J., Lephart, E.D. Reprod. Biol. Endocrinol. (2004) [Pubmed]
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