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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes.

The adaptor protein FADD/MORT1 is essential for apoptosis induced by 'death receptors', such as Fas ( APO-1/ CD95), mediating aggregation and autocatalytic activation of caspase-8. Perhaps surprisingly, FADD and caspase-8 are also critical for mitogen-induced proliferation of T lymphocytes. We generated novel monoclonal antibodies specific for mouse FADD and caspase-8 to investigate whether cellular responses, apoptosis or proliferation, might be explained by differences in post-translational modification and subcellular localisation of these proteins. During both apoptosis signalling and mitogenic activation, FADD and caspase-8 aggregated in multiprotein complexes and formed caps at the plasma membrane but they did not colocalise with lipid rafts. Interestingly, mitogenic stimulation, but not Fas ligation, induced a unique post-translational modification of FADD. These different modifications may determine whether FADD and caspase-8 induce cell death or proliferation.[1]

References

  1. Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes. O'Reilly, L.A., Divisekera, U., Newton, K., Scalzo, K., Kataoka, T., Puthalakath, H., Ito, M., Huang, D.C., Strasser, A. Cell Death Differ. (2004) [Pubmed]
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