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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Uterine rupture associated with misoprostol labor induction in women with previous cesarean delivery.

OBJECTIVE: To review our experience with uterine rupture in patients undergoing a trial of labor with a history of previous cesarean delivery in which labor was induced with misoprostol. STUDY DESIGN: A retrospective chart review was used to select patients who underwent induction of labor with misoprostol during the period from February 1999 to June 2002. Women with a history of cesarean delivery were retrospectively compared with those without uterine scarring. RESULTS: Uterine rupture occurred in 4 of 41 patients with previous cesarean delivery who had labor induced with misoprostol. The rate of uterine rupture (9.7%) was significantly higher in patients with a previous cesarean delivery (P<0.001). No uterine rupture occurred in 50 patients without uterine scarring. Women with a history of cesarean delivery were more likely to have oxytocin augmentation than those without uterine scarring (41% versus 20%; P=0.037). CONCLUSION: Misoprostol induction of labor increases the risk of uterine rupture in women with a history of cesarean delivery.[1]

References

  1. Uterine rupture associated with misoprostol labor induction in women with previous cesarean delivery. Aslan, H., Unlu, E., Agar, M., Ceylan, Y. Eur. J. Obstet. Gynecol. Reprod. Biol. (2004) [Pubmed]
 
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