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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.[1]

References

  1. Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Harman, F.S., Nicol, C.J., Marin, H.E., Ward, J.M., Gonzalez, F.J., Peters, J.M. Nat. Med. (2004) [Pubmed]
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