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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review.

BACKGROUND: Serum levels of parathyroid hormone-related peptide (PTHrP) can be elevated with malignancy and cause hypercalcemia, which has been associated with a poor prognosis. METHODS: We present a case of supraglottic squamous cell carcinoma with elevated serum PTHrP and hypercalcemia. The patient was acutely managed with intravenous fluids, furosemide, and zoledronic acid and then underwent a total laryngectomy and modified radical neck dissection. RESULTS.: The patient remains disease free and normocalcemic. CONCLUSION: Curative treatment for patients with head and neck cancer should not be withheld solely on the basis of humoral hypecalcemia of malignancy.[1]

References

  1. Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review. Brawner, J.T., Zitsch, R.P. Head & neck. (2004) [Pubmed]
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