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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cyclic peptide alkaloids from the bark of Discaria americana.

The isolation and structure determination of cyclic peptide alkaloids, discarine-M and discarine-N, along with seven known cyclic peptide alkaloids, adouetine-Y', franganine, frangulanine, discarines-A, -B, -C, and -D from the root bark of Discaria americana are described. Structures were determined spectroscopically, especially using 2D NMR spectroscopic analysis. The crude methanol extract, the basic ether extract, and the alkaloids 6 and 7 also weakly inhibited growth of gram-negative and gram-positive bacteria.[1]


  1. Cyclic peptide alkaloids from the bark of Discaria americana. Giacomelli, S.R., Maldaner, G., Gonzaga, W.A., Garcia, C.M., da Silva, U.F., Dalcol, I.I., Morel, A.F. Phytochemistry (2004) [Pubmed]
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