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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Paraneoplastic pemphigus secondary to fludarabine evolving into unusual oral pemphigus vegetans.

We report a patient with chronic lymphocytic leukaemia who developed paraneoplastic pemphigus (PNP) soon after the initiation of fludarabine therapy. He presented with severe oral and cutaneous erosions. Initially, he had high titres of circulating autoantibodies as detected by indirect immunofluorescence (IF) on multiple epithelial substrates (normal human skin, monkey oesophagus, and rat bladder) and by desmoglein 1 and 3 enzyme-linked immunosorbent assays (ELISAs). His oral erosions have subsequently progressed into unusual hyperplastic papillomatous lesions affecting the inner aspect of lips and buccal mucosae, histologically consistent with pemphigus vegetans. Desmoglein 1 antibodies and IF on rat bladder substrate have become negative after 18 months of therapy. Several agents had been initiated to bring the disease under control originally, but a partial remission was achieved and maintained with mycophenolate mofetil and low-dose prednisolone.[1]

References

  1. Paraneoplastic pemphigus secondary to fludarabine evolving into unusual oral pemphigus vegetans. Powell, A.M., Albert, S., Oyama, N., Sakuma-Oyama, Y., Bhogal, B., Black, M.M. Journal of the European Academy of Dermatology and Venereology : JEADV. (2004) [Pubmed]
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