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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.[1]

References

  1. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Ruggero, D., Montanaro, L., Ma, L., Xu, W., Londei, P., Cordon-Cardo, C., Pandolfi, P.P. Nat. Med. (2004) [Pubmed]
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