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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tension precedes commitment-even for a stem cell.

The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape- induced changes in Rho GTPase activity and cytoskeletal tension.[1]

References

  1. Tension precedes commitment-even for a stem cell. Settleman, J. Mol. Cell (2004) [Pubmed]
 
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