Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Koulu, M. et al.

Koulu, Movafagh, Tuohimaa, Jaakkola, Kallio, Pesonen, Geng, Karvonen, Vainio-Jylhä, Pöllönen, Kaipio-Salmi, Seppälä, Lee, Higgins, Zukowska,

Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization.

BACKGROUND: Neuropeptide Y is a sympathetic neurotransmitter, a potent endothelium-derived angiogenic factor and a vascular mitogen. We have studied the role of the functional leucine7 to proline7 polymorphism of the signal peptide region of preproneuropeptide Y (prepro-NPY) as a genetic susceptibility factor for diabetic retinopathy. In addition, we investigated the role of the NPY Y2-receptor as a putative mediator of angiogenic NPY signaling in the retina. METHODS: Frequencies of proline7 (Pro7) carriers in the prepro-NPY were determined in type 1 and type 2 diabetes patients having retinopathy, in type 2 diabetes patients without retinopathy and in healthy control subjects. The role of Y2-receptor in hyperoxemia-induced retinal neovascularization was investigated in Y2-receptor knockout mice (Y2-/-) and in rats administered Y2-receptor mRNA antisense oligonucleotide. RESULTS: The carriers having Pro7 in the preproNPY are markedly over-represented among type 2 diabetes patients with retinopathy compared to type 2 diabetes patients without retinopathy and to the population control. Neonatal exposure to hyperoxia resulted in development of retinal neovascularization that was prevented in Y2(-1-) -mice, and significantly inhibited in rats treated with the Y2-receptor antisense oligonucleotide. CONCLUSIONS: NPY and Y2-receptor play important roles in diabetic retinopathy and retinal neovascularization and are thus potential new targets for drug molecules for treatment of retinopathy.[1]

References

Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization. Koulu, M., Movafagh, S., Tuohimaa, J., Jaakkola, U., Kallio, J., Pesonen, U., Geng, Y., Karvonen, M.K., Vainio-Jylhä, E., Pöllönen, M., Kaipio-Salmi, K., Seppälä, H., Lee, E.W., Higgins, R.D., Zukowska, Z. Ann. Med. (2004) [Pubmed]

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