Topical application of the tricyclic antidepressant doxepin can reduce dysuria and frequency

Scand J Urol Nephrol. 2004;38(1):88-9. doi: 10.1080/00365590310017299.

Abstract

The aim of this article is to highlight a novel treatment for the symptoms of chronic urethral and trigonal irritation. A patient with severe urethral hyperaesthesia who derived almost complete alleviation of symptoms with topical application of a tricyclic antidepressant cream is described. The possible modes of action of tricyclics when used via the topical route of administration are described. Topical application of a tricyclic antidepressant cream may alleviate the symptoms of urethral hyperaesthesia.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Antidepressive Agents, Tricyclic / therapeutic use*
  • Dose-Response Relationship, Drug
  • Doxepin / therapeutic use*
  • Drug Administration Schedule
  • Follow-Up Studies
  • Humans
  • Male
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome
  • Urinary Bladder, Neurogenic / complications
  • Urinary Bladder, Neurogenic / diagnosis*
  • Urinary Catheterization
  • Urination Disorders / complications
  • Urination Disorders / diagnosis
  • Urination Disorders / drug therapy*
  • Urodynamics

Substances

  • Antidepressive Agents, Tricyclic
  • Doxepin