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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

To learn better, keep the HAT on.

Long-lasting memories are known to require new transcription. Recent studies have highlighted a role for epigenetic alterations, including histone acetylation, in regulating gene expression. In this issue of Neuron, Alarcón et al. and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein ( CBP) in long-term memory and plasticity.[1]


  1. To learn better, keep the HAT on. Martin, K.C., Sun, Y.E. Neuron (2004) [Pubmed]
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