RB from a bud's eye view.
RB and related proteins block transcriptional activation of genes critical to initiation of the cell cycle and suppress unwanted cell division. The circuitry controlling this response is generally conserved from humans to yeast, but no negative regulator like RB has been found in yeast. In this issue of Cell, two studies reveal that Whi5 appears to play the role of RB in preventing precocious cell cycle entry in budding yeast.[1]References
- RB from a bud's eye view. Schaefer, J.B., Breeden, L.L. Cell (2004) [Pubmed]
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