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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells.

We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of calcitonin receptor-like receptor (CRLR) and receptor activity- modifying protein 1 (RAMP1) or RAMP2. TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR and RAMP1/2 mRNAs, thereby diminishing AM-evoked cAMP production. The suppression of these three mRNAs was unaffected by inhibiting NOS, protein kinase G, protein kinase A, superoxide formation or NF-kappaB activation.[1]

References

  1. Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells. Nagoshi, Y., Kuwasako, K., Cao, Y.N., Imamura, T., Kitamura, K., Eto, T. Peptides (2004) [Pubmed]
 
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