The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

We genotyped 525 independent North American white individuals with systemic lupus erythematosus ( SLE) for the PTPN22 R620W polymorphism and compared the results with data generated from 1,961 white control individuals. The R620W SNP was associated with SLE (genotypic P=.00009), with estimated minor (T) allele frequencies of 12.67% in SLE cases and 8.64% in controls. A single copy of the T allele (W620) increases risk of SLE (odds ratio [OR]=1.37; 95% confidence interval [CI] 1.07-1.75), and two copies of the allele more than double this risk (OR=4.37; 95% CI 1.98-9.65). Together with recent evidence showing association of this SNP with type 1 diabetes and rheumatoid arthritis, these data provide compelling evidence that PTPN22 plays a fundamental role in regulating the immune system and the development of autoimmunity.[1]

References

  1. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Kyogoku, C., Langefeld, C.D., Ortmann, W.A., Lee, A., Selby, S., Carlton, V.E., Chang, M., Ramos, P., Baechler, E.C., Batliwalla, F.M., Novitzke, J., Williams, A.H., Gillett, C., Rodine, P., Graham, R.R., Ardlie, K.G., Gaffney, P.M., Moser, K.L., Petri, M., Begovich, A.B., Gregersen, P.K., Behrens, T.W. Am. J. Hum. Genet. (2004) [Pubmed]
 
WikiGenes - Universities