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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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NAP mechanisms of neuroprotection.

An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-alpha, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.[1]

References

  1. NAP mechanisms of neuroprotection. Gozes, I., Steingart, R.A., Spier, A.D. J. Mol. Neurosci. (2004) [Pubmed]
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