Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Kuriyama, S.N. et al.

In utero exposure to low-dose 2,3',4,4',5-pentachlorobiphenyl ( PCB 118) impairs male fertility and alters neurobehavior in rat offspring.

Neurobehavior (motor activity and developmental reflexes) and male reproductive parameters were evaluated in rat offspring after in utero exposure to a low dose of PCB 118 comparable to human exposure levels. Sprague-Dawley dams were treated on gestation day 6 by gavage with a single dose of 375 microg PCB 118/kg body weight or peanut oil (control). The dose was calculated to be approximately 100-fold higher than that found in human breast milk. Postnatal reflexes, motor activity and male reproductive performance were evaluated in rat offspring after exposure to PCB 118. Evaluation of locomotor activity for five consecutive days during puberty ( PND 70-74) revealed hyperactivity in offspring from PCB 118-exposed dams. In adult males ( PND 170), clear effects on reproductive organs were observed in PCB-exposed animals which had smaller testes, epididymides and seminal vesicles (absolute and relative weights). Decreases in sperm and spermatid numbers and impairment of daily sperm production were also observed. Our results clearly demonstrate that low-dose exposure to PCB 118 alters neurobehavior and impairs adult male fertility in offspring. This is in contrast to the reported increases in sperm production and testis weight in rat after high dose PCB exposures. PCBs appear to possess variable dose-related effects and therefore low-dose studies are important to obtain a complete picture for human risk assessment.[1]

References

In utero exposure to low-dose 2,3',4,4',5-pentachlorobiphenyl (PCB 118) impairs male fertility and alters neurobehavior in rat offspring. Kuriyama, S.N., Chahoud, I. Toxicology (2004) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.