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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligation.

The extraordinary radiation resistance of Deinococcus radiodurans results from the efficient capacity of the bacterium to repair DNA double-strand breaks. By analysing the DNA damage repair-deficient mutant, KH311, a unique radiation-inducible gene (designated pprA) responsible for loss of radiation resistance was identified. Investigations in vitro showed that the gene product of pprA (PprA) preferentially bound to double-stranded DNA carrying strand breaks, inhibited Escherichia coli exonuclease III activity, and stimulated the DNA end-joining reaction catalysed by ATP-dependent and NAD-dependent DNA ligases. These results suggest that D. radiodurans has a radiation-induced non-homologous end-joining repair mechanism in which PprA plays a critical role.[1]

References

  1. PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligation. Narumi, I., Satoh, K., Cui, S., Funayama, T., Kitayama, S., Watanabe, H. Mol. Microbiol. (2004) [Pubmed]
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