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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase.

To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain.[1]

References

  1. Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase. Meng, Y., Takahashi, H., Meng, J., Zhang, Y., Lu, G., Asrar, S., Nakamura, T., Jia, Z. Neuropharmacology (2004) [Pubmed]
 
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