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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion- associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1.

A variety of host factors, including membrane proteins acquired by human immunodeficiency virus type 1 (HIV-1), play a dominant role in HIV-1 adsorption onto host cells. Examples include the integrin intercellular adhesion molecule 1 (ICAM-1), which, once acquired by HIV-1, promotes virus infectivity via ligation to LFA-1. We tested the ability of statins to diminish HIV-1 replication, based on the idea that these compounds have been shown to block ICAM-1- LFA-1 interactions. Our data indicate that statins diminish HIV-1 attachment to target cells by suppressing ICAM-1- LFA-1 interactions. The capacity of statins to limit the initial steps in virus replication could represent an interesting approach for the treatment of HIV-1 infection.[1]

References

  1. Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1. Giguère, J.F., Tremblay, M.J. J. Virol. (2004) [Pubmed]
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