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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells.

Phogrin (IA2-beta) is an integral membrane protein of dense-core vesicles in neuroendocrine cells. We have examined the recycling of endogenous phogrin following exocytosis in insulin secreting Min6 beta-cells by monitoring stimulus dependent-uptake of antibodies directed against the lumenal domain of the protein. While low levels of internalized phogrin accumulated in LAMP1-positive lysosomes, more than 35% of internalized phogrin recycled back to an insulin-positive compartment and could return to the cell surface during a second exocytic stimulation. The recycling phogrin transited a syntaxin 6-positive compartment but did not appear to go through the TGN38-positive trans Golgi network. The results suggest a model in which secretory membrane components can recycle from the endosomal system to immature secretory granules without interaction with the major portion of the TGN.[1]


  1. Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. Vo, Y.P., Hutton, J.C., Angleson, J.K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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