- Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. Takahashi, N., Lopez, M.L., Cowhig, J.E., Taylor, M.A., Hatada, T., Riggs, E., Lee, G., Gomez, R.A., Kim, H.S., Smithies, O. J. Am. Soc. Nephrol. (2005)