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Suzuki, H. et al.

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF- mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF- mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.[1]

References

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Suzuki, H., Kurita, M., Mizumoto, K., Moriyama, M., Aiso, S., Nishimoto, I., Matsuoka, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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