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Barton, J.C.

Barton,

Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases.

BACKGROUND: Iron absorption is decreased in some individuals who have undergone bariatric surgery. METHODS: We evaluated measures of iron metabolism and therapeutic phlebotomy in 3 adults with hemochromatosis and HFE C282Y homozygosity who underwent bariatric surgery. RESULTS: 1 male and 1 female had surgery before diagnosis of hemochromatosis (jejuno-ileal bypass and Roux-en-Y gastric bypass, respectively); neither had iron overload. Another man was treated with serial phlebotomy to induce iron depletion; later, he underwent Roux-en-Y gastric bypass. His maintenance phlebotomy requirement for hemochromatosis decreased substantially (on average approximately 1 unit each 71 days before surgery, and approximately 1 unit each 173 days after surgery). None of these patients developed iron deficiency, and none took supplemental iron. CONCLUSIONS: Iron absorption is decreased in some patients with hemochromatosis and HFE C282Y homozygosity after bariatric surgery, but their risk of developing iron deficiency may be diminished.[1]

References

Hemochromatosis, HFE C282Y homozygosity, and bariatric surgery: report of three cases. Barton, J.C. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2004) [Pubmed]

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