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Vritsali, E. et al.

Acquired macroglossia due to lopinavir/ritonavir treatment.

A HIV-positive patient, 3 months after the treatment initiation with lopinavir-/ritonavir (LPV/r) acquired macroglossia. The tongue biopsy revealed mature adipose tissue accumulated into submucosa. The drug was discontinued and the patient showed a significant improvement. This case is the first case in the medical literature of acquired macroglossia because of LPV/r, a drug causing changes in body fat composition.[1]

References

Acquired macroglossia due to lopinavir/ritonavir treatment. Vritsali, E., Kolokotronis, A., Valagouti, D., Miteloudis, G., Zaraboukas, T., Kioses, V., Antoniades, D. J. Oral Pathol. Med. (2005) [Pubmed]

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