- Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex. Garcia, H.H., Brar, G.A., Nguyen, D.H., Bjeldanes, L.F., Firestone, G.L. J. Biol. Chem. (2005)