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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Localization of human X chromosomal mental retardation ( MRX) genes in chicken and comparison with the chicken genome sequence data.

In an ongoing study human X chromosomal mental retardation genes ( MRX) were mapped in the chicken genome. Up to now the homologs of 13 genes were localized by FISH techniques. Four genes from HSAXp (TM4SF2, RSK2/RPS6KA3, NLGN4, ARX) map to GGA1q13-->q31, and seven genes from HSAXq (OPHN1, AGTR2, ARHGEF6, PAK3, FACL4/ACS4, FMR2, ATRX) to GGA4p. The gene-rich region of HSAXq28 proved to be much less conserved. GDI1 localized to GGA1pter and SLC6A8 to a mid-sized microchromosome. The order of the genes was determined from the newly available genome sequence data from chicken, which reveals exact colinearity between the genes in HSAXp and GGA1q13-->q31, but completely scrambled gene order between the genes with common synteny from HSAXq and GGA4p. This result supports the hypothesis that the human X chromosome is a real ancient autosomal linkage group.[1]

References

  1. Localization of human X chromosomal mental retardation (MRX) genes in chicken and comparison with the chicken genome sequence data. Kohn, M., Kehrer-Sawatzki, H., Hameister, H. Cytogenet. Genome Res. (2005) [Pubmed]
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